About Our Scientific Approach
The Sadhguru Center uses scientific approaches to integrate medical and contemplative sciences to improve brain health and general well-being. Our team conducts research that employs both clinical and mindfulness-based interventions such as multimodal intraoperative general anesthesia, and opioid-sparing effective pain control in the postoperative period to improve post-operative outcomes, particularly related to cognitive decline and delirium that often occur in aged patients.
The Center's work will provide insight into how consciousness, cognition and compassion are aided by meditative practices. With the aid of enhanced functional MRI (fMRI) tools developed over the last decade, there has been a substantial increase in research conducted on how meditative practices change the brain size and neural network connectivity. There are ongoing clinical studies conducted in the Center that explore how meditative practices affect consciousness and cognition, as well as emotional well-being. Work is also underway to create a database of people who have integrated meditation into their daily routine with the goal of evaluating long-term benefits of regular meditation on emotional well-being. Combined, these approaches will help elucidate how meditative practices influence the potential physiological changes.
Ongoing Clinical Trials
Dr. Bala Subramaniam is leading several major clinical trials investigating approaches intended to reduce post-operative cognitive decline in patients that have undergone cardiac surgery. PANDORA, a multicenter clinical trial funded by the National Institute of Aging, is investigating whether analgesic treatments during the perioperative period, particularly the use of acetaminophen, help to reduce delirium. In another trial, PATHFINDER, Dr. Subramaniam uses minimal opioid medication after surgery to determine if this reduces cognitive decline and delirium after cardiac surgery.
Dr. Subramaniam and his team are exploring the novel concept of "prehabilitation" (pre-surgery interventions) to reduce postoperative neurocognitive disorders. On prospective clinical trial uses guided meditative practices performed prior to cardiac surgery. Dr. Subramaniam and colleagues also investigated the feasibility of prehabilitation with neurocognitive techniques to enhance preporative cognition (PEaPoD).
Selected Recent Publications
- Packiasabapathy S, Susheela AT, Mueller A, Patxot M, Gasangwa D, O'Gara B, Shaefi S, Marcantonio ER, Yeh GY, Subramaniam B. Guided meditation as an adjunct to enhance postoperative recovery after cardiac surgery: study protocol for a prospective randomized feasibility trial. Trials 2019; 20(1):39. PMID: 30635064
- Subramaniam B, Shankar P, Shaefi S, Mueller A, O'Gara B, Banner-Goodspeed V, Gasangwa D, Patxot M, *Packiasabapathy S, *Mathur P, Eikermann M, Talmor D, Marcantonio ER. Effect of Postoperative Intravenous Acetaminophen versus Placebo, Combined with Propofol or Dexmedetomidine, on Postoperative In-Hospital Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial. JAMA. 2019. PMID: 30778597
Views: 9495; attention score: 237 (top 5% of all research outputs scored by altmetric, 8 news outlets, reads by all scientific community from all over the world; statistics from JAMA webpage)
- Rangasamy V, *Thampi Susheela A, Mueller A, Chang T, Sadhasivam S, Subramaniam, B. The effect of a one-time 15-minute guided meditation (Isha Kriya) on stress and mood disturbances among operating room professionals: a prospective interventional pilot study [version 1; peer review: awaiting peer review]. F1000Research 2019, 8:335.
- O'Gara B, Marcantonio ER, Mueller A, Shaefi S, Banner-Goodspeed V, Subramaniam B. Prevention of Early Postoperative Decline. A feasibility study. Anesth Analg. 2020; 130(3):586-595. [2019 Sep 27. doi: 10.1213/ANE.0000000000004469, Epub ahead of print]. PMID 31569161.
- Rangasamy V, *Henriques T, Xu X, Subramaniam B. Preoperative Blood Pressure Complexity Indices as a Marker for Frailty in Patients Undergoing Cardiac Surgery. J Cardiothorac Vasc Anesth. 2020; 34(3): 616-621 [2019 Sep 30. pii: S1053-0770(19)31028-6. doi: 10.1053/j.jvca.2019.09.035, Epub ahead of print] PMID: 31668744
- Narayanan S, Reddy A, Lopez G, Liu W, Wu J, Liu D, Manzano J, Willliams JL, Mallaiah S, George M, Amaram J, Subramaniam B, Cohen L, Bruera E. Randomized Feasibility Study of Meditative Practices in Hospitalized Cancer Patients. Integr Cancer Ther. 2020: 19; 1534735420909903. PMID: 32153208
- 7. Sadhasivam S, Alankar S, Maturi R, Vishnubhotla RV, Mudigonda M, Pawale D, Narayanan S, Hariri S, Ram C, Chang T, Renschler J, Eckert G, Subramaniam B. Inner Engineering practices and advanced 4-day Isha Yoga Retreat are associated with Cannabimimetic effects with increased endocannabinoids and short-term and sustained improvement in mental health: A prospective observational study of meditators. Evidence-Based Complementary and Alternative Medicine 2020; Article ID 8438272, 9 pages
For more publications please visit: